MYELOID NEOPLASIA e-Blood BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis
نویسندگان
چکیده
1Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany; 2Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; 4Department of General Pathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany; 5Institute of Neurology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; 6Experimental Anaesthesiology, University Hospital Ulm, Ulm, Germany; 7Department of Pediatric Oncology, Hematology and Immunology, University Children’s Hospital of Heidelberg, Heidelberg, Germany; 8Institute of Pathology, Charité-University Medicine Berlin, Berlin, Germany; and 9Institute of Pathology, Medical University Vienna, Vienna, Austria
منابع مشابه
BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis.
Langerhans cell histiocytosis (LCH) is a clinically and histologically heterogeneous disorder. Its classification as either reactive inflammatory or neoplastic has been a matter of debate. However, the recent finding of frequent BRAFV600E mutations in LCH argues for the latter. The exact cell type that harbors the mutation and is responsible for proliferation remains to be identified. We here a...
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تاریخ انتشار 2012